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however, melatonin successfully reversed these unfavourable changes through its antioxidant properties and ability to modulate mitophagy, contributing to the restoration of CS-induced lung pathological changes ( SIRT1 is an NAD (+)-dependent protein/histone deacetylase that is widely involved in physiological and pathological processes, such as apoptosis (Wu et al., 2022), inflammation (Zhou et al., 2021), and oxidative stress (Rada et al., 2018)

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