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The compounds therapeutic synergy is amplified when combined with photodynamic therapy-3.5 M curcumin with light irradiation enhances autophagic flux while suppressing ERK/AKT-mediated oxidative stress, converting reversible cell cycle arrest to irreversible senescence (Niu et al., 2016)

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The changing expression of SMAD6 and SMAD1, their localization predominantly to vascular endothelial cells, and the roles of ACVRL1 and ENG in angiogenesis support the hypothesis of aberrant tissue remodeling in the lung vasculature during emphysema pathogenesis

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