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Symptoms of vitamin B12, or folate, deficiency can include fatigue, lethargy, low mood, shortness of breath, and nerve problems

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One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition

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Ideal candidates often have specific health conditions or dietary restrictions that lead to a deficiency