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The accumulating precirrhotic liver lesions (fatty infiltration, alcoholic hepatitis, and fibrosis) may be responsible for the weak effects of 6-month LA administration

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Cells were then fixed in 3.7% formaldehyde for 30 min before proceeding to fluorescence staining

Crucially, synergistic interplay between these modalities, such as combining senolytics with epigenetic reprogramming or mTOR inhibition, should be rigorously explored to increase efficacy while minimizing unintended adverse effects