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Abstract Introduction: Motivation is a key driver in achieving goals and performing daily tasks, involving costbenefit valuations of the amount of effort required for a particular reward and can be influenced by socio-environmental factors and neurological conditions that may impact the brain reward circuitry

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Gene expression levels were quantified using htseq-count, and differential expression analysis was performed using DESeq2

This process is accompanied by reduced secretion of cytokines, such as IFN- and TNF-, as well as increased expression of PD-1 and TIM-3

Biochemistry 52(52):94569469 Elbegdorj O, Westkaemper RB, Zhang Y (2013) A homology modeling study toward the understanding of three-dimensional structure and putative pharmacological profile of the G-protein coupled receptor GPR55