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Furthermore, the original co-crystallized ligand inside the active site may affect the conformation of the protein and, as a consequence, the binding mode of other ligands

Clinical Cognitive and Energy Benefits Human studies demonstrate PQQ's effectiveness across multiple measures of cellular function

The clinical evidence for the diverse strategies discussed above, ranging from direct antioxidants to multi-targeted agents, is summarized in Table 1, which illustrates the varied outcomes and highlights the ongoing translational challenges