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10.1016/S1471-4906(03)00237-0 44

Though there is not a single specific serum or plasma biomarker for ALS, higher levels of serum neurofilament light chain (NfL), a neuron-specific marker of axonal degeneration, have been found to differentiate ALS from disease mimics, such as inflammatory demyelinating polyneuropathy or structural polyradiculopathy [78], and correlates with rate of progression in ALS as well as disease severity [79]

in fact, more people in the U.S

Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites

Jin R, Yi Y, Yull FE, Blackwell TS, Clark PE, Koyama T, et al