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The most common side effects are gastrointestinal: nausea (55%), constipation (30.7%), and vomiting (26.1%)

It works by blocking signals in the brain that trigger these symptoms

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Moreover, the matrine-derived compound MASM, which has anticancer and anti-inflammatory effects, has been shown to suppress the transformation of astrocytes into the toxic form, offering benefits in conditions such as autoimmune encephalomyelitis and multiple sclerosis 153

Long term biweekly 1 mg oral vitamin B12 ensures normal hematological parameters, but does not correct all other markers of vitamin B12 deficiency