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cAMP/PKA Steroidogenic Signalling In primary mouse Leydig cell cultures, hCG was found to be approximately 10-fold more potent than LH in cAMP recruitment, and slightly but significantly more potent in cAMP-dependent Erk1/2 phosphorylation though no significant differences were observed at the level of downstream steroidogenic events including Creb phosphorylation, Stard1 gene expression, and testosterone synthesis

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This phenomenon, which is known as the 'somatopause', has led to recombinant human GH being widely promoted and abused as an antiageing drug, despite lack of evidence of efficacy

Going Deeper If you want to explore the broader research on GHK-Cu, our deep dive on the compounds mechanism and literature is here: GHK-Cu: The Copper Peptide in Skin, Wound Healing, and Anti-Aging Research All compounds discussed in this article are for research use only