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This, in turn, especially at extremely high concentrations, has been noticed to induce modications of different molecules, including DNA [ 159 ] and proteins [ 160 ], which ultimately can be one of the major contributors in the pathogenesis of various neurodegenerative diseases [ 161 ]

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The peptide is metabolized primarily by hepatic cytochrome P450 enzymes and excreted renally, with unchanged dihexa detectable in urine for up to six hours

In vivo denervation experiments C57BL/6 or Sox2eGFP mice were administered with analgesics 30 min prior to surgery (carprofen and buprenorphine