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demonstrated a substantial decrease in GPX3 levels in renal tissues obtained from both IR-induced AKI mouse models and clinical AKI patients, with a positive correlation observed between GPX3 levels and the severity of renal injury

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Additionally, it downregulates SLC7A11 channel protein expression while upregulating ALOX3, further promoting ferroptosis ( Multiple studies have also revealed that Saikosaponin A can induce ferroptosis in hepatocellular carcinoma (HCC) cells, both in laboratory settings and in living organisms

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