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NQO1, also a Nrf2 target enzyme, was also found to be increased in astrocytes, endothelial cells, and dopaminergic neurons in postmortem PD brains (Schipper et al

Endothelial impairment and bone marrow-derived CD34 + /133 + cells in diabetic patients with erectile dysfunction

10.1096/fj.02-0092fje 57

Chronic hyperglycemia can cause macrovascular complications such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, and microvascular complications, including retinopathy, nephropathy, and neuropathy [7]

Dalvi MP, Wang L, Zhong R, Kollipara RK, Park H, Bayo J, Yenerall P, Zhou Y, Timmons BC, Rodriguez-Canales J, Behrens C, Mino B, Villalobos P, Parra ER, Suraokar M, Pataer A, Swisher SG , Kalhor N, Bhanu NV, Garcia BA, Heymach JV, Coombes K, Xie Y, Girard L, Gazdar AF, Kittler R, Wistuba II, Minna JD, Martinez ED