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There is an inactivating point mutation in ALDH2 (named ALDH2*2) with low enzymatic activity [25]

Another study [42] found that the level of mercury-related porphyrins (coproporphyrin and precoporphyrin) had a significant correlation with their severity of autism as rated by the Childhood Autism Rating Scale (CARS)

(MIC 0.1254 g/mL) and potentiates multiple antifungal drugs (Gao et al., 2020)

Thus, many patients require lifelong treatment to dampen the immune mechanisms driving the diseases, thereby alleviating the symptoms

Additionally, the available clinical trials did not measure the biomarkers of oxidative damage, so its mechanism of action may not be indeed related to the antioxidant effects