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Note : Beta-blockers are generally not recommended as first-line therapy for blood pressure reduction except in those with an indication for beta-blocker therapy such as recent heart attack or heart failure

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This is accomplished with inhibition of the serotonin transporter protein or sensitization of serotonin receptors or inhibits MA, alterations in the transmission of GABAergic and/or glutamatergic transmitters, increase BDNF, effect on concentrations of serotonin in the synaptic cleft and act on dopamine

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