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Role of GH Signaling in Cancers Growth hormone and its mediated signaling pathways are involved in the development of multiple cancer types, particularly colon, breast, and endometrial cancers according to in vitro , in vivo , and epidemiological analyses

doi: 10.1186/1471-2458-10-595 95

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both increase ROS accumulation in key regions like the gut and brain, contributing to cellular senescence, neuroinflammation, and cognitive dysfunction (Wang et al., 2010

Biochemically, LCD proceeds upon LMP when cells are exposed to various lysosomotropic detergents (e.g., lipid metabolites (phosphatidic acid, sphingosine), ROS), including cathepsins [178,179,180,181] (Fig