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All ingredients utilized to create the chitosan-coated NLCs were purchased from Sigma Aldrich, St

However, the clinical translation of nanomedicine remains challenging because of the limitations of expensive and time-consuming clinical development [45], limitations of animal models for preclinical testing [46,47,48], uncertainty of nanotherapeutics, and evolving regulatory environment [49]

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Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline Solubility: 2.08 mg/mL (4.12 mM)

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