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In addition, the accumulation of BCAAs can over-activate mTOR, which not only leads to a phenotypic transformation of vascular smooth muscle cells, causing mitochondrial ROS damage and triggering vascular inflammation (65), but also mediates the upregulation of IL-6 and TNF-

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In contrast, no appreciable communication was observed between the GSH of the IMS and matrix (Kojer et al., 2012)

doi: 10.1002/mds.27681 125 SamiiACarletonBCEtminanM