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Description

10.1371/journal.pone.0113609 52 JornsC.EllisE

FOXO4-DRI is a D-amino acid retro-inverso peptide that disrupts the intracellular interaction between FOXO4 and p53 in senescent cells, triggering p53-mediated apoptosis selectively in senescent rather than healthy proliferating cells

Notably, the compound is stable across a wide pH range and fully soluble in aqueous media, unusual properties for a peptide of this size that are attributed to its high proportion of proline and charged residues