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Moreover, treatment with IPA inhibited Th17 differentiation and glucose uptake in both in vivo and in vitro settings, and protein and gene expression of glycolytic markers, such as HK2, LHDA, and HIF1, was also down-regulated

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FIGURE 3 4.1 Exacerbation of renal TECs injury Impairment of FAO results in the excessive accumulation of cytotoxic lipid speciessuch as triglycerides, free fatty acids (FFAs), cholesterol, and lysophosphatidylcholinewithin TECs

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The microporous membranes were cut out from each insert and lysed in 0.02% sodium dodecyl sulfate (SDS) in ddH 2 O