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Although genetic alterations contribute to resistance, increasing evidence indicates that epigenetic regulation and non-genetic cellular plasticity are primary drivers of drug-tolerant and relapse-initiating states

Notably, EGCG has been studied in various tumor cell lines and less frequently in animal models

Chromatographic analysis was performed using the Shimadzu high-performance liquid chromatography (HPLC) system composed of two quaternary pumps, an autosampler (model 20ACHT), and a diode array detector (DAD) (model SPD-M20A) and a C18 (ODS) reverse phase (150 mm 4.5 mm) column

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