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In addition to its effects on lipid metabolism and gut microbiota, berberine exhibits antioxidant and anti-inflammatory activities, which are vital for mitigating liver inflammation and oxidative stress commonly seen in NAFLD

In planta mutations of the cherI gene resulted in clear phenotypes (e.g., reduced phospho- and choline levels in fully developed leaves and stunted growth), but supplying cherI mutant plants with exogenous choline did not rescue these strong phenotypes (28)