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The MET inhibitor cabozantinib and MET shRNA knockdown significantly reduced their tumourigenicity in vitro and in vivo and reduced the population of CSCs

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In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

Ferroptosis: mechanisms, biology and role in disease