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Therapeutic strategies targeting the gut microbiota include conventional probiotics, prebiotics, and fecal microbiota transplantation, alongside emerging synthetic biology approaches employing genetically engineered probiotic strains to deliver bioactive molecules, including GLP-1, directly in the gut microenvironment

Studies in animals with medically induced kidney injury found that hydrangea extract significantly reduced BUN levels ( One of these studies also observed less kidney damage in mice treated with the extract, compared with a control group ( Another study similarly found that skimmin, an active molecule found in hydrangea extract, reduced BUN, blood creatinine, and urinary albumin excretion (UAE) in mice with kidney inflammation

Its the parent compound from which PT-141 (Bremelanotide) was derived a peptide that achieved full FDA approval

in a larger Ladakhi cohort, which revealed that seven EGLN1 polymorphisms (rs1538664, rs479200, rs2486729, rs2790879, rs480902, rs2486736 and rs973252) were strongly correlated with HAPE susceptibility

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