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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

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Furthermore, owing to the potential of multi-organ involvement, multidisciplinary care is often required [109,110,111,112]

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that is, literally, every metabolic pathway in our bodies has been mapped outnot just the major players and pathways, but also the minor pathways and metabolites. By having such well-defined cellular biochemistry that includes the biochemical reactants, the metabolic intermediates, and all the necessary enzymes, cofactors, vitamins, minerals, etc