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Description

in vitro/in vivo metabolism by cells from the same donor

Bloodbrain barrier permeability is induced in AOM mice via a mechanism involving the TGF 1-driven SMAD3-dependent upregulation of MMP9 expression and decrease of claudin-5 expression

Activated protein C however has not been explored for its protection over BBB integrity in the context of MS, but rather for its anti coagulation effects, reducing disease severity in MS models [128]