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HSA can also undergo post-translational modifications, under some diseased and other such states which can influence its drug-interaction capabilities

The HER Foundation is advancing current guidelines by developing a comprehensive treatment algorithm to help clinicians in managing HG

2022 May 13 [cited 2024 Nov 11];12Available from Bai D, Chen T, Xun J, Ma C, Luo H, Yang H, et al

Buthionine sulfoximine (BSO), a substrate mimetic with poor drug-like properties, currently represents one of the best currently available GCL inhibitors [5]

Using all three strategically gives you short-term impact and long-term sustainability