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Although preclinical evidence suggests that GLP-1RAs can cross the blood-brain barrier (BBB), the efficacy of CNS delivery and the precise therapeutic dosage necessary to achieve neuroprotective concentrations in people are unclear

A combined biomaterial and cellular approach for annulus fibrosus rupture repair

W., Wold, L

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Additional risk factors include: Age over 60 years (reduced stomach acid production) Autoimmune conditions (thyroid disease, vitiligo, type 1 diabetes) Family history of pernicious anaemia Chronic alcohol consumption Diagnosis and Testing Diagnosis of vitamin B12 deficiency anaemia requires a combination of clinical assessment, laboratory investigations, and sometimes specialist testing