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HIF-1, the oxygen-sensitive subunit of the HIF-1 transcriptional complex, is stabilized under hypoxic conditions and triggers a cascade of cellular responses (Koh and Powis, 2012)

MOv19), coupled to the T-cell receptor chain CD3, in combination with a CD137 (4-1BB) costimulatory motif, were successful in inducing tumor regression in pre-clinical models