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In 1891, it was found to be useful to treat malaria, thus making methylene blue "the first synthetic compound ever used as an antiseptic in clinical therapy and the first antiseptic dye to be used therapeutically," according to the authors of a Medicinal Research Reviews paper on the compound

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Moreover, HGF prevents NMDA-induced neuronal death in hippocampal neuron cultures in vitro by blocking pro-apoptotic caspase-3 activation and translocation of AIF into the nucleus (Ishihara et al., 2005)

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