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The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

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In a randomized, double-blind, placebo-controlled clinical study in 67 patients with severe traumatic brain injury, intravenous administration of dexanabinol (48 mg or 150 mg) within 6 hours of injury resulted in lower intracranial pressure and a reduced number of hypotensive episodes, indicating improvements in cerebral edema

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they cross the blood-brain barrier, altering neurotransmitter balance and contributing significantly to the sensation of "brain fog" and central nervous system fatigue