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Summary MSM supplements are generally considered safe

316 These same probiotic strains have previously been shown to reduce psychological distress in healthy volunteers

Additionally, we evaluate and support patients experiencing neurological symptomssuch as numbness, tingling, cognitive changes, or peripheral neuropathywhen a B12 deficiency is suspected or confirmed through laboratory testing

Brain and Development 27, 297300

In practice, and in view of clonazepams adverseeffect profile, a short, timelimited course of the combination during the initial 4 weeks may be considered when rapid quality of life improvement is prioritized, whereas liquid NAC monotherapy is likely sufficient over an 8week horizon for patients for whom minimizing benzodiazepine exposure is preferred