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La gran mayora de los datos proviene de estudios in vivo realizados en modelos murinos y de rata, as como de experimentos in vitro en cultivos celulares

Its incorporation into essential selenoproteins, such as GPx and TrxR, is fundamental to neutralizing ROS and preserving cellular homeostasis

First, targeting of mature OLs without off-targets on the immature stages of the OL lineage may be important, given their differential susceptibilities to injury and responses to extrinsic factors