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Glutathione synthetase deficiency: Is -glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione

The receptors then migrate to one side of the endosome, whereas the LDLs stay free within the lumen of the vesicle

Phase I Detoxification: The First Step Enzymatic Transformation Makes Toxins More Soluble Phase I enzymes begin the detoxification process by chemically transforming fat-soluble compounds into water-soluble compounds

Incubation of Fischer-344 rat nasal mucosal homogenate with acrolein resulted in a concentration-dependent increase in DNA-protein cross-linking, which was not observed following inhalation exposure of rats to acrolein at a concentration of 4.6 mg/m 3 for 6 h (Lam et al., 1985)