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The combination works through complementary mechanisms: GLP-1 agonist appetite suppression caloric deficit forces the body to use stored energy AOD-9604 directly stimulates fat cells to release that stored energy + inhibits new fat storage In practice, users report that AOD-9604 helps address stubborn fat deposits particularly visceral and lower abdominal fat that persist even on effective GLP-1 therapy

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The idea of selectively modifying gene expression in specific vascular beds to control fat tissue growth represents a longer-term vision