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467,468 Table 3 presents notable clinical studies regarding the application of ICIs in the treatment of TNBC

25 : 945961 Pettegrew JW, Minshew NJ, Spiker D, Tretta M, Strychor S, McKeag D et al

In disease-causing TNFRSF1A variants, the autophagy system is defective leading to apoptosis and elevated production of mitochondrial-derived reactive oxygen species (ROS) (42)

[DOI] [PubMed] [Google Scholar] 22.Chang B, et al

These findings highlight the important role of the carnitine pool as a bridge between cellular metabolism and epigenetic regulation and open the possibility of developing novel therapeutic strategies targeting specific metabolic and epigenetic targets