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1 REIMAGINE 2 was a 68-week phase 3 trial evaluating the safety and efficacy of CagriSema in doses 2.4 mg/2.4 mg and 1 mg/1 mg once weekly versus semaglutide 2.4 mg, semaglutide 1 mg, cagrilintide 2.4 mg, and dose-matched placebo in 2,713 adults with T2D inadequately controlled with metformin with or without an SGLT2 inhibitor

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Accessible multiomics signatures of zinc-dependent organelle dysfunction Organelle-specific zinc imbalance produces characteristic transcriptional, proteomic and metabolomic consequences that may be detectable in accessible biospecimens such as blood, cerebrospinal fluid or urine

doi: 10.1002/mnfr.200900460 101

demonstrated that ultrasmall Pt NPs coated with polyvinylpyrrolidone, which can effectively scavenge ROS, inhibit macrophage polarization to decrease the expression of inflammatory factors, and downregulate MMPs to regenerate type I collagen to alleviate UV-induced skin photoaging [20]