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10.14188/j.1671-8852.2012.05.003 38 WangS

MOTS-c was found to upregulate key genes in the TGF-/Smad pathway (such as TGF-1, TGF-2, and Smad7) and increase the expression of bone formation markers like alkaline phosphatase (ALP), osteocalcin, and Runx2 in bone cells

Int J Mol Sci 20(23):5896 McGrath EP, Centonze FG, Chevet E, Avril T, Lafont E (2021) Death sentence: the tale of a fallen endoplasmic reticulum

It also discusses key challenges in their development and explores future directions, including clinical considerations and emerging research with triple agonists