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RTV impedes the enzyme cytochrome P450-CYP3A4, which is responsible for the metabolism of xenobiotics, and therefore RTV induces an increase in intracellular drug concentrations in the patient (Zeldin and Petruschke, 2004)

Spatiotemporal dynamics of metabolic-immune crosstalk Microglial metabolic plasticity (e.g., M1 phenotype relying on glycolysis vs

ScGrx7 is poorly susceptible to competitive inhibitors To test the catalytic mechanism in more detail, we performed inhibition studies with S -methylglutathione or L--glutamyl-L--aminobutyrylglycine (ophthalmic acid)

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