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Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study

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[20] Patients should contact their GP or bariatric team promptly if they experience any of the following: New or worsening tingling, numbness, or weakness in the limbs Difficulty with balance, coordination, or memory Unexplained fatigue, breathlessness, or palpitations A sore or swollen tongue, or persistent mouth ulcers Any concern that they have missed supplementation for a prolonged period Symptoms that suggest anaemia, such as pallor or dizziness New or worsening neurological symptoms such as paraesthesia, gait disturbance, or cognitive change warrant same-day assessment

202 Additional meta-analyses have also concluded that probiotics, prebiotics, and synbiotics can reduce oxidative stress, decrease inflammation, improve lipid levels, and heighten glucose metabolism in CKD patients