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Description

At 8 weeks, the new bone filled and mineralized the defect

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Similarly, Liang and colleagues employed single-cell RNA sequencing to demonstrate that PS-NPs markedly suppress the transcription of ATP metabolism-associated genes (e.g., Atp5a1 , Cox7a2 ) in dopamine neurons of the mouse nigrostriatal pathway 33

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The analysis identified the upregulation of two kinase families: casein kinase (CSNK, p = 0.031) and mitogen-activated protein kinase (MAPK, including p38 kinase, p = 3.65 10 11 ) (Fig