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Description

Sermorelin becomes the priority when a patients goals or presentation shift toward body composition, muscle retention, and structural recovery

5 However, for neurotoxic metabolites to enter the brain, the bloodbrain barrier (BBB), which is not permeable to these neurotoxins in normal physiological conditions, must be disrupted

However, the mechanism may reasonably apply to GLP-1 therapy as well

Key implications Study protocols must justify the relevance of each patient-reported outcome (PRO)

Pericytes-mediated regulation of CBF Brain pericytes express contractile and cytoskeletal proteins that can modify CBF by adjusting their contractile tone and diameter [39, 99]