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Receptor binding patterns, intracellular transport mechanisms, and potential off-target effects remain incompletely characterized

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Furthermore, a 2024 bidirectional Mendelian randomization study confirmed the causal relationship between depression and chronic constipation genetically (OR = 11.43, 95% CI: 1.8570.67, P = 0.008), while the reverse analysis did not identify a significant causal effect of constipation on depression, suggesting that depression may be an upstream factor in the development of chronic constipation (He et al., 2024)

But if youre under stress all the time you stay in the acute phase and you dont go back down into homeostasis

I was supposed to have my 6 month in May, but it just wasnt in the cards at the time