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Combining them can duplicate cysteine exposure and is not automatically more effective

Treatment with Fer-1, Lip-1, or neural stem cell-derived extracellular vesicles enriched in CDC42 substantially attenuates cerebrovascular damage and cognitive deficits in PD mice (Li et al., 2025b)

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They concluded that GSH is the primary sulfur receptor of SQOR in vivo , and proposed a simplified pathway in which SQOR oxidizes H 2 S to generate glutathione persulfide (GSSH), which is then converted to sulfite and sulfatethus avoiding the need for sulfite to directly cross membranes ( 2 S oxidation flux in liver and heart, respectively