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Semaglutide doses range from 0.25mg to 2.4mg, much lower than tirzepatide doses of 2.5mg to 15mg

Donadieu M, Le Fur Y, Lecocq A, Maudsley AA, Gherib S, Soulier E, et al

The Role of Neurosteroids in Memory Deficits Associated With Stress and Anxiety Disorders Three large scale major neural networksthe default mode network, central executive network, and salience networkcontribute to cognitive processing within the human brain and function together to facilitate adaptive responses of the CNS (286)

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Independent of the species that triggers aggregation, it is generally accepted that a gain-of-function toxicity of the expanded ATXN3 protein contributes highly to SCA3 pathology