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Biochem Pharmacol 1998

It is likely that circulating coenzyme Q 10 concentrations are decreased because statins reduce circulating lipids rather than because they inhibit coenzyme Q 10 synthesis (124)

We selected the G12D and G12V mutations because of their high frequency across all KRAS-driven cancers (including colorectal cancer) (Figure S1A), G12C for its high prevalence only in lung adenocarcinoma, and G12A because it is infrequently observed in colorectal adenocarcinoma yet biochemically indistinguishable from G12V 7

c-Myc can directly bind to the promoter regions of PHGDH and PSAT1 and promote their transcription, a mechanism that has been validated in breast cancer and glioblastoma (64, 98, 99)