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Sci Rep-Uk (2017) 7(1):7007

Molecules released by dying or stressed cells, such as ATP, HMGB1, CRT and proinflammatory cytokines, can all be used as adjuvants or danger signals of the immune system, and such signals are collectively called DAMPs (83)

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Consistently, cell lines with abrogation of G2/M phase upon combination treatment, i.e., NCI-H520 and NCI-HCC15 also presented a reduction of the expression of p21 CIP/WAF1 and p-ATM, the latter involved in the DNA damage response pathway (Supplementary Figs