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Moreover, expression of VEGFR-1 on pericytes acts as a regulator of tip cell formation in mice retinas and inhibiting this signal causes overgrowth of the vascular field (133)

The treating physician should ensure the patient has understood and acknowledged the risks of congenital malformations and neurodevelopmental disorders including the magnitude of these risks for children exposed to Divalproex sodium/Valproate/Valproic Acid in utero