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More than 32,000 unique variants have been identified, including over 800 pathologic mutations of ABCB11

However, the porous structure introduced a longer response time (~82 s) due to diffusion delays within the pore network

The His236, Asp282, and Ser379 residues constitute the active site catalytic triad of the active protease

Recent single-cell and single-nucleus transcriptomic studies have already delineated more than nine transcriptionally distinct astrocyte clusters, underscoring both the complexity of astrocytic heterogeneity and the inadequacy of traditional binary classification schemes 20,61

doi: 10.1523/JNEUROSCI.6119-09.2010 93 KakioA.NishimotoS