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Bacterial toxins, including cytotoxic necrotizing Factor 1, cytolethal distending toxins, Bacteroides fragilis toxins, and bacteria-driven hydrogen sulfide and superoxide radicals, have been determined to trigger DNA damage to induce carcinogenesis

doi: 10.1016/j.envexpbot.2023.105424

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These results indicate that NRF2 plays a key role in mediating Mat1a ASO-induced hepatocyte FGF21 secretion

Excessive lipid retention disrupts very low-density lipoprotein (VLDL) secretion, exacerbating hepatic steatosis and serving as a precursor to DH