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Administration of E2 has been shown to enhance mitochondrial function in the liver while simultaneously decreasing the production of reactive oxygen species (ROS) and mitigating insulin resistance in rat models (45)

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In addition to these responses, which are mostly common to all types of abiotic stress, some proteins are synthesized specifically according to the nature of the stress: Osmoprotectants such as proline and glycinebetaine [xix] (osmotic stress, including water stress), HSP (Heat Shock Proteins, during high temperature stress), Proteins against aggregation/inactivation such as LEA (Late Embryogenesis Abundant Protein) during drought or cold stress, etc

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